Important Safety Information
IMPORTANT SAFETY INFORMATION
Do not take VYVGART HYTRULO if you are allergic to efgartigimod alfa, hyaluronidase, or any of the ingredients in VYVGART HYTRULO. VYVGART HYTRULO can cause serious allergic reactions and a decrease in blood pressure leading to fainting.
Before taking VYVGART HYTRULO, tell your healthcare provider about all of your medical conditions, including if you:
- have an infection or fever.
- have recently received or are scheduled to receive any vaccinations.
- have any history of allergic reactions.
- have kidney (renal) problems.
- are pregnant or plan to become pregnant. It is not known whether VYVGART HYTRULO will harm your unborn baby.
- Pregnancy Exposure Registry. There is a pregnancy exposure registry for women who use VYVGART HYTRULO during pregnancy. The purpose of this registry is to collect information about your health and your baby. Your healthcare provider can enroll you in this registry. You may also enroll yourself or get more information about the registry by calling 1-855-272-6524 or going to VYVGARTPregnancy.com
- are breastfeeding or plan to breastfeed. It is not known if VYVGART HYTRULO passes into your breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
VYVGART HYTRULO can cause side effects which can be serious, including:
- Infection. VYVGART HYTRULO may increase the risk of infection. If you have an active infection, your healthcare provider should delay your treatment with VYVGART HYTRULO until your infection is gone. Tell your healthcare provider right away if you get any of the following signs and symptoms of an infection:
- fever
- chills
- frequent and painful urination
- cough
- pain and blockage of nasal passages
- wheezing
- shortness of breath
- sore throat
- excess phlegm
- nasal discharge
- Allergic reactions (hypersensitivity reactions). VYVGART HYTRULO can cause allergic reactions that can be severe. These reactions can happen during, shortly after, or weeks after your VYVGART HYTRULO injection. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
- rash
- swelling of the face, lips, throat, or tongue
- shortness of breath
- hives
- trouble breathing
- low blood pressure
- fainting
- Infusion or injection-related reactions. VYVGART HYTRULO can cause infusion or injection-related reactions. These reactions can happen during or shortly after your VYVGART HYTRULO injection. Tell your healthcare provider if you have any of the following symptoms of an infusion or injection-related reaction:
- high blood pressure
- fainting
- shivering
- chest stomach or back pain
The most common side effects of VYVGART HYTRULO include respiratory tract infection, headache, urinary tract infection, and injection site reactions.
These are not all the possible side effects of VYVGART HYTRULO. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is VYVGART HYTRULO® (efgartigimod alfa and hyaluronidase-qvfc)?
VYVGART HYTRULO is a prescription medicine used to treat adults with chronic inflammatory demyelinating polyneuropathy (CIDP).
It is not known if VYVGART HYTRULO is safe and effective in children.
Please see the full Prescribing Information and Patient Information for VYVGART HYTRULO.
Dosage forms and strengths:
VYVGART Hytrulo is available as a single-dose subcutaneousinjection containing: 200 mg/mL of efgartigimod alfa and 2,000 U/mL of hyaluronidase per prefilled syringe, or 180 mg/mL of efgartigimod alfa and 2,000 U/mL of hyaluronidase per vial.
VYVGART and VYVGART Hytrulo are registered trademarks of argenx.
For U.S. audiences only.
©2026 argenx US-VYV_HYT-24-00157 V3 02/2026
Explore VYVGART Hytrulo, by argenx
VYVGART Hytrulo is a prescription medicine for adults with chronic inflammatory demyelinating polyneuropathy (CIDP) and is the first innovation in CIDP treatment in over 30 years.
VYVGART Hytrulo is available for subcutaneous self-injection with a prefilled syringe.
*VYVGART Hytrulo contains efgartigimod alfa and hyaluronidase, and is specifically designed to attach to FcRn receptors. FcRn=neonatal Fc receptor.
About argenx
argenx is a global leader in immunology, developing medicines for people with severe autoimmune diseases, including CIDP. Driven by innovation, we developed the first in-class FcRn blocker, offering solutions for people living with rare autoimmune disease.
An Overview of VYVGART Hytrulo
A one-of-a-kind treatment—now in your hands.
A different approach to CIDP
- Works differently than other CIDP treatments, including IVIg, SCIg, PLEX,and steroids
- The first and only plasma-free treatment approved by the FDA for CIDP
- Self-inject in about 20-30 seconds once weekly with a prefilled syringe, which can mean more time in your day for the people and things you love*
*Please see Patient Information. Follow appropriate administration steps in the Instructions for Use. Monitor for signs and symptoms of an allergic reaction for at least 30 minutes aſter injection. If an allergic reaction occurs, you should seek medical attention. IVIg=intravenous immunoglobulin; PLEX=plasma exchange; SCIg=subcutaneous immunoglobulin.
Ask your doctor if VYVGART Hytrulo is right for you.
Getting ready for your next appointment and looking for helpful resources? Call the VYVGART Hytrulo Education Line. Our Health Educators are available 6 days a week (Monday through Saturday, 8 AM to 9 PM ET).
Call 1-833-VYV-CIDP (1-833-898-2437) to speak with an educator.
How VYVGART Hytrulo Is Administered
Self-inject in about 20-30 seconds once weekly, so more of the day can be yours.*
The VYVGART Hytrulo prefilled syringe can go where you go. Self-inject wherever you can properly complete the injection—whether at home or a hotel.
- It’s a single injection delivered under the skin (subcutaneously)—not into a vein
- Self-inject with the prefilled syringe that contains a single dose of VYVGART Hytrulo
- If you miss an injection, you have a 3-day window to make it up before returning toyour dosing schedule
- With VYVGART Hytrulo, you can self-inject, or a caregiver can do it for you. You canstill get your injection from a healthcare professional
- You and/or your caregiver will receive in-person training at home or in your doctor’s office until you’re ready to inject on your own. You’ll also get a demonstration kit to help you practice
*Please see Patient Information. Follow appropriate steps and storage and handling guidance in the Instructions for Use. Monitor for signs and symptoms of an allergic reaction for at least 30 minutes aſter injection. If an allergic reaction occurs, you should seek medical attention.
Patient Support Program
My VYVGART Path
It may feel overwhelming getting started on a new treatment. With My VYVGART Path, you’ll have access to resources and one-on-one support throughout your treatment journey.
My VYVGART Path is a Patient Support Program that pairs you with a dedicated Nurse Case Manager (NCM) who will provide support throughout your treatment journey—all just a phone call away, including:
- A personalized understanding of your treatment: My VYVGART Path NCMs are knowledgeable about VYVGART Hytrulo and are dedicated to listening to you and answering questions you may have
- Empowering resources and information: NCMs can support you throughout your treatment journey to help you in following your doctor’s treatment plan
- Hands-on help navigating the insurance process: Dealing with insurance can be complicated. An NCM can help answer questions you have and help navigate the insurance process
- Helpful information about a co-pay program and financial assistance programs: If you have financial concerns or gaps in insurance coverage for your VYVGART Hytrulo therapy, an NCM is here for you with information and support. They can also help confirm if you’re eligible to pay as little as $0 for VYVGART Hytrulo and related administration costs
Once you’ve been prescribed VYVGART Hytrulo, you’re eligible to join My VYVGART Path. Enroll now at enrollMVP.com or ask your doctor to help.
Already enrolled? Ask your NCM about the VYVGART Hytrulo prefilled syringe for self-injection. 1-833-MY-PATH-1 (1-833-697-2841)
Downloadable Patient Resource
Download the VYVGART Hytrulo Patient Brochure to discover more about VYVGART Hytrulo—including how it works, what makes it a different approach to CIDP treatment, its safety and effectiveness, and how to receive personalized support.
Check out the CIDP Doctor Discussion Guide and share your experience with your neurologist. Download this tool that can help you take note of symptoms and theirimpact on daily life, so you can take charge of conversations with your doctor.
Watch the science behind VYVGART Hytrulo: The science of CIDP can get complex, but this video breaks it down simply. Travel into the body to see how CIDP works and get a better understanding of the science behind VYVGART Hytrulo.
Sign up for the latest VYVGART Hytrulo news and be the first to hear about exciting events for the CIDP community and caregivers—plus get access to helpful CIDP resources.
Ask your neurologist if VYVGART Hytrulo for CIDP is right for you or your loved one.
