Diagnosis and management of Guillain–Barré syndrome in ten steps
Authors: Sonja Leonhard, Melissa Mandarakas, Francisco de Assis Aquino Gondim, Kathleen Bateman, Maria Lúcia Ferreira, David Cornblath, Pieter van Doorn, Mario Dourado, Richard Hughes, Badrul Islam, S Kusunoki, Carlos Pardo, Ricardo Reisin, Jim Sejvar, Nortina Shahrizaila, Cristiane Soares, Thirugnanam Umapathi, Yuzhong Wang, Eppie Yiu, Hugh Willison, and Bart Jacobs.
Previously, no international clinical guidelines for the diagnosis and management of the Guillain-Barré syndrome (GBS) existed. This was problematic, as clinical presentation and disease course may vary extensively between patients, management can be difficult, and clinicians are often confronted with diagnostic and treatment dilemmas. Furthermore, the incidence of GBS may suddenly and dramatically increase, as was seen recently during the Zika virus epidemic in during 2015-2016 in Latin America and the Caribbean. To accommodate for this unmet need and to support clinicians, especially during new outbreaks of GBS, we developed a globally-applicable, simple and practical clinical guideline for GBS.
This guideline is based on current literature and international expert consensus, presenting a 10-step approach to facilitate use in clinical practice. These 10 steps cover the most important aspects of diagnosis, treatment, monitoring, prognosis and long-term management. Furthermore, tables and figures are provided that give an overview of diagnostic criteria, clinical variants and differential diagnoses of GBS. These are helpful resources for busy clinicians, that can be printed and used at the bedside. To complement the paper, we have finalized a web-based resource that presents the information in an easy-to-access online format.