Propionate Exerts Neuroprotective and Neuroregenerative Effects in the Peripheral Nervous System

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Propionate Exerts Neuroprotective and Neuroregenerative Effects in the Peripheral Nervous System

A  recent study from Ruhr-University Bochum, Germany, was able to demonstrate that the short-chain fatty acid, propionate, has a protective and regenerative effect on the peripheral nervous system in cell culture and in animal experiments.

Dr. Thomas Grüter who headed the cell culture and animal experiments states, “hereby, propionate addresses a different effect than therapies approved so far. Propionate has already shown an anti-inflammatory and protective effect in studies with multiple sclerosis patients, and we have now also been able to demonstrate a regenerative effect in the peripheral nervous system. These results are the basis of the clinical trial of the effect of propionate in CIDP patients.” This clinical trial with CIDP patients is funded by the GBS|CIDP Foundation 2021 Discovery Award and headed by award recipient Dr. Anna Lena Fisse.

The full article was recently published in the medical journal “Proceedings of the National Academy of Sciences of the United States of America.” Click here for full article.