grants

Now Accepting Applications for 2020 Research Grants

As part of the GBS|CIDP Foundation International’s mission to provide education and support research, we offer research grants to qualified applicants. Grants are made possible through the benevolence of many sources, including the Helen S. Manheimer Research Fund, contributions from individuals who have been personally touched by GBS or CIDP and by several commercial sources. Through the generosity of these contributors, to whom the Foundation is most grateful, we are able to offer a Research Grant Program. The GBS|CIDP Foundation International has worldwide representation, sharing resources with local support group chapters nationally and internationally.

Foundation interests include GBS, both demyelinating and axonal variants, Miller Fisher syndrome, CIDP, Multifocal Motor Neuropathy, and others. Research interests cover a broad range of subjects including development of methods to more rapidly diagnose these disorders, creation of educational and communication programs to inform patients and families of the Foundation’s availability, identification of mechanisms involved in the pathogenesis of family disorders, development of more effective treatments to limit the disease process, prevent complications and reduce long-term adverse sequelae.

Learn More about GBS|CIDP Foundation International 2020 Research Grant Opportunity

2018 Research Grant Finalists Announced

Research is critical to serving the cause and the community. The GBS-CIDP Foundation International believes in supporting research by funding grants for projects that contribute to the knowledge and advancement of treatment of GBS|CIDP and variants of the condition.

We are pleased to announce our 2018 Research Grant Awardees are as follows: 

1. Principal Investigator: Elisabetta Babetto, Ph.D., Research Assistant Professor

The Research Foundation for SUNY on behalf of U. at Buffalo

Project: “Targeting Wallerian-like degeneration in GBS mouse models”

Synopsis: Axon degeneration accounts for the most debilitating clinical symptoms of Guillain Barré Syndrome (GBS). Our goal is to explore the mechanisms of axon loss in this condition, by testing the hypothesis that axon degeneration in GBS is governed by a defined molecular program amenable for therapeutic intervention. Specifically we will test whether inactivation of proteins, known to dictate axon loss after experimental injury, affords axon terminal protection in murine models of GBS.


2. Principal Investigators: Luana Benedetti, MD, PhD and  Lucilla Nobbio, PhD

University of Genova, ITALY

Project: Sphingomyelin dosage in GBS/CIDP patients: biomarker validation in a multicenter, prospective study

Synopsis: The identification of a biomarker specific and sensitive to improve diagnostic accuracy, to monitor disease activity, to stage patients, and to select specific treatments is a prime goal for the GBS/CIDP Community. Due to the encouraging results we obtained by dosing SM levels in the CSF of patients affected by GBS and CIDP, we propose the present study whose major significance is to validate our results on a sizeable and carefully selected number of patients.


3. Principal Investigator: Paolo Ripellino, MD, Neurologist

Neurocenter of Southern Switzerland

Project: (IGOS) in Switzerland: a deeper look into HEV-induced GBS

Synopsis: This study will increase the amount of clinical and prognostic data of the IGOS consortium with the inclusion of patients from an important area located in the middle of Europe. The high quality of the Swiss health care system will allow researchers to obtain accurate data. The systematic collection of acute phase samples in a biobank will be fundamental for future international, cooperative studies. The subproject about the role of HEV is innovative because – although so far neglected – HEV is an increasing, preventable (by appropriate cooking and blood donors testing) disease and this infection is associated to GBS.


4. Principal Investigator: Luis Querol MD PhD

Hospital de la Santa Creu i Sant Pau, Barcelona

Project:  Disease-specific Biomarkers In Inflammatory Neuropathies

Synopsis: Inflammatory neuropathies (IN) are disorders in which disease-specific biomarkers are not required or diagnostic purposes, leading to disease heterogeneity. We discovered the association of anti-contactin-1 antibodies to a specific CIDP subset using an unbiased approach. This strategy has also proven effective in antibodies against NF155 and nodal neurofascins in CIDP, in which our group has also played a central role. The discovery of paranodal antibodies hasboosted translational research in the field, including the description of specific pathology, genetic background (DRB1*15 association with NF155 antibodies), response to treatment and animal models, supporting the idea that the classification of IN according to disease-specific biomarkers would make IN research and care more efficient.


5. Principal Investigator: Dr Laura Zambreanu, MD, MRCP

National Hospital for Neurology and Neurosurgery, UK

Project:  Intravenous immunoglobulin and intravenous methylprednisolone as optimal induction treatment in CIDP (OPTIC trial)

Synopsis:  Most CIDP patients are treated with regular intravenous immunoglobulin (IVIg) because of fast improvement and rare adverse events, but IVIg is expensive. Corticosteroid treatment is associated with longer time to improvement and more side effects, but may lead to long-term remission1,2. We intend to participate in a multicentre, randomized, double-blind, placebo-controlled superiority trial in patients with active CIDP. The primary objective is to assess whether combining IVIg and intravenous methylprednisolone (IVMP) leads to more frequent long-term remission in CIDP compared to IVIg alone. Patients will be recruited in the Netherlands and the UK.

 

Congratulations to all and thank you for your continued commitment to research in the area of GBS|CIDP and variants of the condition.

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