Progress: There remains a great deal of work that is needed to answer these questions but progress is being made. Recognizing that the primary site of attack in MMN is at the Node of Ranvier now points to the axon as being primarily involved. Attack on the nodes does not only cause CB, but also affects the energy transport down the nerve fiber which over time can cause degeneration of the must vulnerable aspects of the nerve, the distal twigs that are farthest from the cell body. This concept is being considered in other disorders that affect the nodes but needs further study in MMN. Some of the axonal elements at the nodes of ranvier may be amenable to therapy.
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