Guillain-Barr� (Ghee-yan Bah-ray) Syndrome, also called acute inflammatory demyelinating polyneuropathy and Landry's ascending paralysis, is an inflammatory disorder of the peripheral nerves those outside the brain and spinal cord.  It is characterized by the rapid onset of weakness and, often, paralysis of the legs, arms, breathing muscles and face.  GBS is the most common cause of rapidly acquired paralysis in the United States today, affecting one to two people in every 100,000.

The disorder came to public attention briefly when it struck a number of people who received the 1976 Swine Flu vaccine.  It continues to claim thousands of new victims each year, striking any person, at any age, regardless of gender or ethnic background.

It typically begins with weakness and/or abnormal sensations of the legs and arms.  It can also affect muscles of the chest, face and eyes.  Although many cases are mild, some patients are virtually paralyzed.  Breathing muscles may be so weakened that a machine is required to keep the patient alive.  Many patients require an intensive care unit during the early course of their illness, especially if support of breathing with a machine is required.  Although most people recover, the length of the illness is unpredictable and often months of hospital care are required. The majority of patients eventually return to a normal or near normal lifestyle, but many endure a protracted recovery and some remain wheelchair-bound indefinitely.

How is GBS Diagnosed?

Quite often, the patient's symptoms and physical exam are sufficient to indicate the diagnosis. The rapid onset of (ascending) weakness, frequently accompanied by abnormal sensations that affect both sides of the body similarly, is a common presenting picture. Loss of reflexes, such as the knee jerk, are usually found. To confirm the diagnosis, a lumbar puncture to find elevated fluid protein and electrical test of nerve and muscle function may be performed.

How is GBS Treated?

What Causes GBS?

The cause is not known. Perhaps 50% of cases occur shortly after a microbial� (viral or bacterial) infection such as a sore throat or diarrhea.  Some theories suggest an autoimmune mechanism, in which the patient's defense system of antibodies and white blood cells are triggered into damaging the nerve covering or insulation, leading to weakness and abnormal sensation.